Leevi
ALStuttu:n jäsen
Hei,
Tämä on ensimmäinen postaukseni palstalle, aiheesta jota olen pohtinut alustavasti. En haun avulla ainakaan löytänyt palstalta aiempaa keskustelua ALS:n ja vuotavan suolen ("intestinal permiability" / "leaky gut syndrome") välisestä yhteydestä. Oheinen hiiritutkimus herättää itselläni kysymyksen olisiko vuotavan suolen hoitamisesta apua ALS-potilaille? Mikäli esim. vuotava suoli on aiheuttanut inflammaatio-tilan.
Sen diagnosointiin on olemassa laboratoriotesti ja hoitokeinojakin on.
https://en.wikipedia.org/wiki/Intestinal_permeability
https://en.wikipedia.org/wiki/Leaky_gut_syndrome (jonka mukaan syndrooman käsite on kiistanalainen)
Physiol Rep. 2015 Apr;3(4). pii: e12356. doi: 10.14814/phy2.12356.
Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model.
Wu S1, Yi J2, Zhang YG1, Zhou J3, Sun J4.
Abstract
Emerging evidence has demonstrated that intestinal homeostasis and the microbiome play essential roles in neurological diseases, such as Parkinson's disease. (ei oleellista tekstiä poistettu) Although the death of motor neurons is a hallmark of ALS, other organs may also contribute to the disease progression. We examined the gut of an ALS mouse model, G93A, which expresses mutant superoxide dismutase (SOD1(G93A)), and discovered a damaged tight junction structure and increased permeability with a significant reduction in the expression levels of tight junction protein ZO-1 and the adherens junction protein E-cadherin. Furthermore, our data demonstrated increased numbers of abnormal Paneth cells in the intestine of G93A mice. Paneth cells are specialized intestinal epithelial cells that can sense microbes and secrete antimicrobial peptides, thus playing key roles in host innate immune responses and shaping the gut microbiome. A decreased level of the antimicrobial peptides defensin 5 alpha was indeed found in the ALS intestine. These changes were associated with a shifted profile of the intestinal microbiome, including reduced levels of Butyrivibrio Fibrisolvens, Escherichia coli, and Fermicus, in G93A mice. The relative abundance of bacteria was shifted in G93A mice compared to wild-type mice. Principal coordinate analysis indicated a difference in fecal microbial communities between ALS and wild-type mice. Taken together, our study suggests a potential novel role of the intestinal epithelium and microbiome in the progression of ALS.
Pitempi julkaisuversio: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425962/
Tämä on ensimmäinen postaukseni palstalle, aiheesta jota olen pohtinut alustavasti. En haun avulla ainakaan löytänyt palstalta aiempaa keskustelua ALS:n ja vuotavan suolen ("intestinal permiability" / "leaky gut syndrome") välisestä yhteydestä. Oheinen hiiritutkimus herättää itselläni kysymyksen olisiko vuotavan suolen hoitamisesta apua ALS-potilaille? Mikäli esim. vuotava suoli on aiheuttanut inflammaatio-tilan.
Sen diagnosointiin on olemassa laboratoriotesti ja hoitokeinojakin on.
https://en.wikipedia.org/wiki/Intestinal_permeability
https://en.wikipedia.org/wiki/Leaky_gut_syndrome (jonka mukaan syndrooman käsite on kiistanalainen)
Physiol Rep. 2015 Apr;3(4). pii: e12356. doi: 10.14814/phy2.12356.
Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model.
Wu S1, Yi J2, Zhang YG1, Zhou J3, Sun J4.
Abstract
Emerging evidence has demonstrated that intestinal homeostasis and the microbiome play essential roles in neurological diseases, such as Parkinson's disease. (ei oleellista tekstiä poistettu) Although the death of motor neurons is a hallmark of ALS, other organs may also contribute to the disease progression. We examined the gut of an ALS mouse model, G93A, which expresses mutant superoxide dismutase (SOD1(G93A)), and discovered a damaged tight junction structure and increased permeability with a significant reduction in the expression levels of tight junction protein ZO-1 and the adherens junction protein E-cadherin. Furthermore, our data demonstrated increased numbers of abnormal Paneth cells in the intestine of G93A mice. Paneth cells are specialized intestinal epithelial cells that can sense microbes and secrete antimicrobial peptides, thus playing key roles in host innate immune responses and shaping the gut microbiome. A decreased level of the antimicrobial peptides defensin 5 alpha was indeed found in the ALS intestine. These changes were associated with a shifted profile of the intestinal microbiome, including reduced levels of Butyrivibrio Fibrisolvens, Escherichia coli, and Fermicus, in G93A mice. The relative abundance of bacteria was shifted in G93A mice compared to wild-type mice. Principal coordinate analysis indicated a difference in fecal microbial communities between ALS and wild-type mice. Taken together, our study suggests a potential novel role of the intestinal epithelium and microbiome in the progression of ALS.
Pitempi julkaisuversio: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425962/
