Tieteellisesti dokumentoidut paranemistapaukset

Leevi

ALStuttu:n jäsen
Tässä yksi tieteellisesti dokumentoitu paranemistapaus:
https://www.ncbi.nlm.nih.gov/pubmed/28641283?dopt=Abstract

49-vuotiaalla miehellä oli diagnosoitu PMA-variantti ALS:sta.
Tehty amalgaamisaneeraus, DPMS-hoito, yhdessä alfalipoiinihapon ja seleenin kanssa, lisäksi vitamiineja ja pienoisravintotekijöitä ja kasvisruokavalio. Parani kolmessa vuodessa. Alla tarkemmin.


Complement Med Res. 2017;24(3):175-181. doi: 10.1159/000477397. Epub 2017 Jun 12.
[Healing of Amyotrophic Lateral Sclerosis: A Case Report].
[Article in German]
Mangelsdorf I, Walach H, Mutter J.

Abstract
BACKGROUND:
Amyotrophic lateral sclerosis (ALS) is a devastating disease leading to death within 3-5 years in most cases. New approaches to treating this disease are needed. Here, we report a successful therapy.

CASE REPORT:
In a 49-year-old male patient suffering from muscle weakness and fasciculations, progressive muscular atrophy, a variant of ALS, was diagnosed after extensive examinations ruling out other diseases. Due to supposed mercury exposure from residual amalgam, the patient's teeth were restored. Then, the patient received sodium 2,3-dimercaptopropanesulfate (DMPS; overall 86 × 250 mg in 3 years) in combination with α-lipoic acid and followed by selenium. In addition, he took vitamins and micronutrients and kept a vegetarian diet. The excretion of metals was monitored in the urine. The success of the therapy was followed by scoring muscle weakness and fasciculations and finally by electromyography (EMG) of the affected muscles. First improvements occurred after the dental restorations. Two months after starting therapy with DMPS, the mercury level in the urine was increased (248.4 µg/g creatinine). After 1.5 years, EMG confirmed the absence of typical signs of ALS. In the course of 3 years, the patient recovered completely.

CONCLUSIONS:

The therapy described here is a promising approach to treating some kinds of motor neuron disease and merits further evaluation in rigorous trials.
 

Leevi

ALStuttu:n jäsen
toinen tapaus:

https://www.ncbi.nlm.nih.gov/pubmed/11332188

Rinsho Shinkeigaku. 2000 Nov;40(11):1090-5.
[A patient with motor neuron syndrome clinically similar to amyotrophic lateral sclerosis, presenting spontaneous recovery].
[Article in Japanese]
Miyoshi K1, Ohyagi Y, Amano T, Inoue I, Miyoshi S, Tsuji S, Yamada T, Kira J.

Abstract

We report a patient with motor neuron syndrome similar to amyotrophic lateral sclerosis (ALS) and with spontaneous recovery. At the age 40, the woman developed progressive muscular weakness, atrophy and fasciculation in extremities. She also noted a dyspnea, tongue atrophy and dysphagia. A neurological examination 6 months after onset revealed i) a tongue atrophy and fasciculation, ii) diffuse muscule weakness and atrophy in face, neck and extremities, and iii) marked hyperreflexia in the four limbs and bilateral Babinski reflex, but iv) neither sensory disturbance nor ophthalmoplegia. Electromyogram (EMG) detected such denervation potentials as fibrillation potentials, fasciculation potentials, positive sharp waves and polyphasic or giant MUPs diffusely in the limb muscles. Peripheral nerve conduction study detected neither conduction block nor delay. Thus, she was diagnosed as suffering from ALS. However, since approximate 1 year after onset, her muscle weakness has gradually been getting better. Simultaneously, the dyspnea and dysphagia gradually improved. Two years after onset, an EMG examination detected chronic denervation potentials in the left musculus sternocleidomastoideus and a few on-going denervation potentials in the left musculus extensor carpi radialis, but no denervation potentials in other limb muscles. Fasciculation potentials were found in tongue muscles. Thus, the present case was thought to have a reversible motor neuron syndrome clinically quite similar to ALS. A mild increase in IgE (346 U/ml) and a low-titer IgM-class anti-GM1 antibody were found in her serum though its pathological significance was uncertain. Any immunological aberrance may account for the pathogenesis. It should be noted that clinically diagnosed cases of ALS may rarely recover spontaneously.
 
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