Leevi
ALStuttu:n jäsen
Tätä on tutkittu aiemminkin, mutta uusi meta-analyysi on nyt julkaistu: Sen johtopäätös on että alkoholin käyttö vähentää ALS:n riskiä.
Neurol Sci. 2016 Apr 21. [Epub ahead of print]
Association between alcohol consumption and amyotrophic lateral sclerosis: a meta-analysis of five observational studies.
E M1,2, Yu S3, Dou J1, Jin W1, Cai X1, Mao Y1, Zhu D1, Yang R4.
Abstract
The purpose of this study is to examine the association between alcohol consumption and amyotrophic lateral sclerosis. Published literature on the association between alcohol consumption and amyotrophic lateral sclerosis was retrieved from the PubMed and Embase databases. Two authors independently extracted the data. The quality of the identified studies was evaluated according to the Newcastle-Ottawa scale. Subgroup and sensitivity analyses were performed and publication bias was assessed. Five articles, including one cohort study and seven case-control studies, and a total of 431,943 participants, were identified. The odds ratio for the association between alcohol consumption and amyotrophic lateral sclerosis was 0.57 (95 % confidence interval 0.51-0.64). Subgroup and sensitivity analyses confirmed the result. Evidence for publication bias was detected. Alcohol consumption reduced the risk of developing amyotrophic lateral sclerosis compared with non-drinking. Alcohol, therefore, has a potentially neuroprotective effect on the development of amyotrophic lateral sclerosis.
Neurol Sci. 2016 Apr 21. [Epub ahead of print]
Association between alcohol consumption and amyotrophic lateral sclerosis: a meta-analysis of five observational studies.
E M1,2, Yu S3, Dou J1, Jin W1, Cai X1, Mao Y1, Zhu D1, Yang R4.
Abstract
The purpose of this study is to examine the association between alcohol consumption and amyotrophic lateral sclerosis. Published literature on the association between alcohol consumption and amyotrophic lateral sclerosis was retrieved from the PubMed and Embase databases. Two authors independently extracted the data. The quality of the identified studies was evaluated according to the Newcastle-Ottawa scale. Subgroup and sensitivity analyses were performed and publication bias was assessed. Five articles, including one cohort study and seven case-control studies, and a total of 431,943 participants, were identified. The odds ratio for the association between alcohol consumption and amyotrophic lateral sclerosis was 0.57 (95 % confidence interval 0.51-0.64). Subgroup and sensitivity analyses confirmed the result. Evidence for publication bias was detected. Alcohol consumption reduced the risk of developing amyotrophic lateral sclerosis compared with non-drinking. Alcohol, therefore, has a potentially neuroprotective effect on the development of amyotrophic lateral sclerosis.